Galatasaray have been drawn in Group A of the Champions League. They will face Bayern Munich, Manchester United and Copenhagen.
Sanchez’s exit in particular could leave Postecoglou sweating over the fitness of his defenders. It will mean Eric Dier, 18-year-old signing Ashley Phillips and left-back Ben Davies are the only back-up options for the centre-back position.
Micky van de Ven has impressed since his initial £34.5million move from Wolfsburg in early August. He has built an exciting partnership at the back alongside Cristian Romero.
Postecoglou will be hoping his first-choice duo can stay fit between now and January. Spurs’ exit from the Carabao Cup means they will only have Premier League football to contend with after missing out on European qualification altogether last season.